FluoBolt™- NOGGIN

Noggin is a homodimer-secreted glycoprotein that acts as an antagonist of bone morphogenetic proteins (BMPs). Human Noggin cDNA encodes a 232 amino acid (AS) long precursor protein, which is cleaved into a 19 AS signalling peptide and the 213 AS long mature protein. This contains an N-terminal acidic region, a central, basic heparin-binding segment and a C-terminal cysteine knot structure. Noggin is very highly conserved among vertebrates. NOGGIN mainly binds BMP-4 and BMP-2 and neutralises their bioactivity by preventing binding to type 1 and type 2 BMP receptors.