FluoBolt™- PERIOSTIN

PERIOSTIN (UniProtKB – Q15063), also known as osteoblast-specific factor 2 (OSF-2), is a cell adhesion protein belonging to the fasciclin domain-containing protein family. It consists of 836 amino acids (aa), starting with a 21 aa long signal sequence, followed by a cysteine-rich emilin, four fasiclin 1- and a C-terminal variable domain, which differs in the 7 splice variants (isoforms). PERIOSTIN is expressed during ontogenesis, but also particularly in mechanically stressed adult tissues such as bones, tendons, heart valves, the skin or the peridontium. It is also found in the aorta, the stomach, the lower digestive tract, the placenta, the uterus, the thyroid gland and breast tissue. In the bone, PERIOSTIN interacts with collagen type 1, fibronectin, Notch 1, tenascin-C and BMP-1, which leads to proteolytic activation of lysyl oxidase and subsequently to stabilisation of the bone matrix through cross-linking of the collagen. Apart from its role in the formation, maintenance and healing of tissue, PERIOSTIN is also highly relevant in carcinogenesis, as it interacts with various cell surface receptors and thus inactivates integrin-dependent signalling pathways, for example. This can lead to increased cell adhesion and mobility, which is important for both tumour growth and metastasis.