Cov19 FluoBolt™-DUO SN

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus strain responsible for coronavirus disease 2019 (COVID-19) and the pandemic. SARS-CoV-2 emerged in China in December 2019 and is mainly transmitted via droplets and surface contact routes. Symptoms can be signs and symptoms of an acute respiratory illness such as fever, cough, shortness of breath, but the infection can also be asymptomatic.
The virus infects human cells by interacting with the angiotensin-converting enzyme 2 (ACE2) on the surface of cells in the respiratory tract and spike (S) protein on the outer envelope of the virion particle, in particular with its receptor binding domain (RBD). The S and the nucleocapsid protein (NC) are the main immunogens of SARS-CoV-2. Antibodies against the RBD of the S protein are considered neutralising, as they can block the interaction with the ACE2 receptor and thus prevent cellular infiltration.
The emergence of more and more immunoinvasive and/or infectious variants and declining immunity after infection or vaccination creates an ongoing need for SARS-CoV-2 antibody measurements.

Therefore, to complement our SARS-Cov-2 serology portfolio, we have decided to utilise our FluoBolt™ technology to develop a


In contrast to our “Cov19 FluoBoltTM-DAT” (Art. No. FIA-1707-FC5), this new assay is not epitope-specific and therefore allows the quantitative measurement of a broad spectrum of antibodies against the S1RBD and the NC antigen of SARS-CoV-2 on separate plates.

This results in excellent clinical agreement and correlation with many other assays used in SARS-Cov-2 serology:

Bestellnummer: FIA-1708-FC5

Anti-S1RBD and anti-NC antibodies present in patient serum or plasma samples bind to NC protein and the S1RBD coated on separate Metal Enhanced Fluorescence-Microtitre Plates (MEF-MTP). Bound antibodies are detected using Cy5-labelled anti-human antibodies. Calibrators with known levels of anti-S1RBD and anti-NC antibodies are used to generate calibration curves to quantify the antibody concentration of an unknown sample.

Daher ist der "Cov19 FluoBoltTM-DUO SN" die beste Wahl für vergleichende Assay-Studien.

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Remote Fingerstick Blood Collection for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Testing.
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Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Test Results With Persistent Physical Symptoms Among French Adults During the COVID-19 Pandemic. Matta J et al.,JAMA Intern Med. 2022 Jan 1;182(1):19-25

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